Organization of an echinoderm Hox gene cluster
نویسندگان
چکیده
منابع مشابه
Organization of an echinoderm Hox gene cluster.
The Strongylocentrotus purpuratus genome contains a single ten-gene Hox complex >0.5 megabase in length. This complex was isolated on overlapping bacterial artificial chromosome and P1 artificial chromosome genomic recombinants by using probes for individual genes and by genomic walking. Echinoderm Hox genes of Paralog Groups (PG) 1 and 2 are reported. The cluster includes genes representing al...
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Background: Hox gene collinearity relates the sequential location of Hox genes in the 3’ to 5’ direction on the chromosome with the linear arrangement of the body elements along the anterior-posterior (A/P) axis of bilaterian embryos. This spatial Hox gene collinearity has been almost universally respected in diverse organisms like worms, insects or vertebrates. It is therefore surprising that ...
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tors, contribute to the specification of neuronal subtype identities, and promote neuronal migration and differentiation. Little is known, however, on the molecular mechanisms underlying the gene regulatory functions of proneural factors. The identity of their target genes, and how do they co-ordinately regulate the neurogenic program is not known. These issues cannot be addressed in the mouse ...
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While the highly consistent gene order and axial colinear patterns of expression seem to be a feature of vertebrate hox gene clusters, this pattern may be less well conserved across the rest of the bilaterians. We report the first deuterostome instance of an intact hox cluster with a unique gene order where the paralog groups are not expressed in a sequential manner. The finished sequence from ...
متن کاملChromatin organization and global regulation of Hox gene clusters
During development, a properly coordinated expression of Hox genes, within their different genomic clusters is critical for patterning the body plans of many animals with a bilateral symmetry. The fascinating correspondence between the topological organization of Hox clusters and their transcriptional activation in space and time has served as a paradigm for understanding the relationships betw...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.4.1469